Salawu O.A., Tijani A.Y., Obidike I.C., Chindo B.A.
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria
Salawu, O.A., Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria; Tijani, A.Y., Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria; Obidike, I.C., Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria; Chindo, B.A., Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria
Piliostigma reticulatum (DC) Hoechst (Leguminosae) is an evergreen shrub reputed to possess a number of medicinal properties. The methanolic extract of Piliostigma reticulatum root (Leguminosae) was evaluated for anti-diarrhoeal activity in rats using castor oil-induced diarrhoea and fluid accumulation and activated charcoal test models. Phytochemical screening revealed the presence of tannins, glycosides, saponins, sterols, alkaloid and balsam. The extract (at doses of 100 and 200 mg/kg) and atropine (3 mg/kg) significantly inhibited castor oil-induced diarrhoea (53.5 72.1%) and fluid accumulation (35.17 71.03%) and small intestinal transit (9.38 21.74%) in the rats. The results obtained in this study revealed that the extract has remarkable anti-diarrhoeal effect, which may be due to the presence of the tannins, alkaloids and saponins constituents and can thus be used in the treatment of non-specific diarrhoea.
alkaloid; antidiarrheal agent; atropine; balsam; castor oil; glycoside; methanol; Piliostigma reticulatum extract; plant extract; saponin; sterol; tannin derivative; unclassified drug; animal experiment; animal model; article; controlled study; diarrhea; drug mechanism; drug screening; drug structure; female; gastrointestinal transit; male; nonhuman; Piliostigma reticulatum; plant; rat