Okokon J.E., Antia B.S., Igboasoiyi A.C., Essien E.E., Mbagwu H.O.C.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria; Department of Chemistry, University of Uyo, Uyo, Nigeria; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, N
Okokon, J.E., Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria; Antia, B.S., Department of Chemistry, University of Uyo, Uyo, Nigeria; Igboasoiyi, A.C., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria; Essien, E.E., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria; Mbagwu, H.O.C., Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
The in vivo antiplasmodial activity of the ethanol seed extract of Picralima nitida grown particularly for the leaf and seed in Niger Delta region of Nigeria was evaluated in Plasmodium berghei berghei infected mice. Picralima nitida (35-115 mg/kg day) exhibited significant (P < 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time though not comparable to that of the standard drug, chloroquine, 5 mg/kg day. The seed extract possesses significant (P < 0.05) antiplasmodial activity which correlate with it reported in vitro activity. © 2007.
chloroquine; Picralima nitida extract; plant extract; unclassified drug; animal experiment; animal model; Apocynaceae; article; controlled study; drug dose comparison; drug efficacy; drug mechanism; female; malaria; male; mouse; nonhuman; parasitosis; picralima nitida; Plasmodium berghei; seed; survival; Animals; Antimalarials; Apocynaceae; Chloroquine; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Malaria; Male; Mice; Phytotherapy; Plant Extracts; Plasmodium berghei; Seeds; Survival Rate; Mus; Picralima nitida; Plasmodium berghei