Evaluation of the anti-inflammatory properties of Chlorophora excelsa stem bark extract
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria; Department of Pharmacology, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Nigeria; Department of Physiology, Olabisi O
A methanol extract of the stem bark of Chlorophora excelsa (Welw.) Benth and Hook was evaluated for anti-inflammatory activity in different models. Acute inflammatory effects were studied in the carrageenan-induced rat paw edema, and the effect of the extract in chronic inflammation was evaluated using the cotton pellet granuloma test. The effect of the extract on topical inflammation induced with croton oil was also tested in mice. The extract produced a significant (p. < 0.05) and dose-dependent inhibition of the carrageenan-induced pedal edema, as well as granuloma tissue formation in rats. Topical anti-inflammatory effect was only evident with 400 mg/kg of the extract. This study demonstrated acute, chronic, and topical anti-inflammatory properties of the methanol extract of C. excelsa. © 2005 Taylor & Francis Ltd.
antiinflammatory agent; carrageenan; Chlorophora excelsa extract; croton oil; hydrocortisone; indometacin; methanol; plant extract; unclassified drug; animal experiment; animal model; antiinflammatory activity; article; Chlorophora excelsa; chronic inflammation; controlled study; dose response; drug isolation; drug screening; granuloma; inflammation; male; medicinal plant; mouse; nonhuman; paw edema; tree; tree trunk; Animalia; Chlorophora excelsa; Gossypium hirsutum