Magaji M.G., Mohammed M., Magaji R.A., Musa A.M., Abdu-Aguye I., Hussaini I.M.
Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria; Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria; Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria; D
Magaji, M.G., Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria; Mohammed, M., Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria; Magaji, R.A., Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria; Musa, A.M., Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria; Abdu-Aguye, I., Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria; Hussaini, I.M., Department of Pharmacology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
Securinega virosa (Roxb ex. Willd) Baill. is a plant which is commonly used in African traditional medicine in management of mental illness. Previous study showed that the crude methanolic root bark extract of the plant possesses antipsychotic activity. In this study, the antipsychotic potential of the residual aqueous fraction of the plant was evaluated using two experimental models, apomorphine induced stereotypic climbing behaviour and swim induced grooming, all in mice. The effect of the fraction on haloperidol-induced catalepsy was also evaluated. The fraction significantly reduced the mean climbing score at the highest dose tested (500 mg/kg). In the swim-induced grooming test, the fraction significantly and dose-dependently (125-500 mg/kg) decreased the mean number and mean duration of swim-induced grooming activity in mice. Similarly, the standard haloperidol (1 mg/kg) significantly (p < 0.001) decreased the mean grooming episodes and duration. However, the fraction did not significantly potentiate haloperidol-induced catalepsy. These results suggest that the residual aqueous fraction of methanol root bark extract of Securinega virosa contains biological active principle with antipsychotic potential. © 2014 Springer Science+Business Media.
apomorphine; clozapine; haloperidol; methanol; neuroleptic agent; olanzapine; plant extract; risperidone; Securinega virosa root bark extract; unclassified drug; apomorphine; haloperidol; neuroleptic agent; plant extract; solvent; water; animal experiment; animal model; antipsychotic activity; article; bark; climbing; controlled study; dose response; drug activity; grooming; haloperidol-induced catalepsy; medicinal plant; mouse; nonhuman; plant root; residual aqueous fraction; securinega virosa; sniffing; stereotypy; African medicine; animal; bark; catalepsy; chemically induced; chemistry; comparative study; disease model; dose response; drug effects; drug screening; Euphorbiaceae; female; isolation and purification; male; phytotherapy; plant root; swimming; Mus; Securinega virosa; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Euphorbiaceae; Female; Grooming; Haloperidol; Male; Medicine, African Traditional; Methanol; Mice; Phytotherapy; Plant Bark; Plant Extracts; Plant Roots; Solvents; Stereotyped Behavior; Swimming; Water