Adedokun M., Essien G., Uwah T., Umoh R., Josiah I., Jackson C.
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria; Department of Clinical Pharmacy and Biopharmacy, University of Uyo, Nigeria; Department of Pharmacognosy and Natural Medicine, University of Uyo, Nigeria
Adedokun, M., Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria; Essien, G., Department of Clinical Pharmacy and Biopharmacy, University of Uyo, Nigeria; Uwah, T., Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria; Umoh, R., Department of Pharmacognosy and Natural Medicine, University of Uyo, Nigeria; Josiah, I., Department of Pharmacognosy and Natural Medicine, University of Uyo, Nigeria; Jackson, C., Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria
Microcrystalline cellulose coded MCC-D was obtained from the stem pulp of sugar cane (Saccharum officinarum) by a two-stage sodium hydroxide delignification process followed by sodium hypochlorite bleaching and hydrochloric acid hydrolysis. The product was examined for its physicochemical properties, powder flow characteristics in relation to Avicel(R) PH 101. Wet granulation method was used to formulate various batches of tablets using MCC-D and Avicel® PH 101 as binders at varying concentrations. The tablets were subjected to the following test: weight uniformity, disintegration and dissolution, and all conformed to official monograph. The extraction yield of MCC-D from the alpha cellulose was very good (70%w/<inf>w</inf>). The flow indices showed that both MCC-D has good flow with Hausner index of 1.13. MCC-D compacts showed excellent weight uniformity, disintegration time and dissolution rate in those with not too high concentration and conforming to British Pharmacopoeia and United States pharmacopoeia specifications. The study revealed that microcrystalline cellulose derived from the stem pulp of Saccharum officinarum has good potential for use as an excipient in tablet formulation. © 2014, Pharmainfo Publications. All rights reserved.
cellulose; dextrin; microcrystalline cellulose; paracetamol; starch; angle of repose; Article; bleaching; bulk density; carrs index; delignification; drug release; drug solubility; hausners index; hydrolysis; nonhuman; parameters; pH; solubility; sugarcane; tablet disintegration; tablet weight; tap density