Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria
Okorie, O., Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria; Nwachukwu, N., Department of Pharmaceutics and Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria
Three hydrophilic polymers as binder matrices in the formulation of chloroquine phosphate tablets were evaluated. Detarium microcarpium seed gum (DMSG), a natural gum was compared with acacia (a natural gum) and sodium carboxymethylcellulose (NaCMC), a synthetic gum as matrices in the formulation of conventional release chloroquine phosphate. Both acacia and NaCMC served as standards. Chloroquine phosphate tablets were formulated with 1% w/w, 2% w/w, 3% w/w and 4%w/w of DMSG, acacia (AC) and NaCMC using the wet granulation method. Granules prepared on evaluation showed flow rate of 5. 80 ± 0. 22 g/s to 10. 40 ± 0. 00 g/s, angle of repose values of 26. 00 ± 0. 05 to 30. 05 ± 0. 10 °, Carrs Index values of 3. 64 ± 0. 00 to 7. 94 ± 0. 01, and Hausner's quotient values 1. 05 ± 0. 00 to 1. 09 ± 0. 01 for all batches. The tablets obtained from the compressed granules were evaluated for uniformity of weight, hardness, friability, content of active ingredient and in vitro dissolution profile. Tablets were found to conform to British Pharmacopoeia standards. DMSG was found to compare favorably with both AC and NaCMC.