Department of pharmaceutics and pharmaceutical technology, University of Port Harcourt, Choba, Port Harcourt, Rivers State, Nigeria
Okorie, O., Department of pharmaceutics and pharmaceutical technology, University of Port Harcourt, Choba, Port Harcourt, Rivers State, Nigeria; Nwachukwu, N., Department of pharmaceutics and pharmaceutical technology, University of Port Harcourt, Choba, Port Harcourt, Rivers State, Nigeria; Ibezim, C.N.E., Department of pharmaceutics and pharmaceutical technology, University of Port Harcourt, Choba, Port Harcourt, Rivers State, Nigeria
The defatted seed gum of Detarium microcarpium (Squill and Sperr), a naturally occurring hydrophilic polymer was investigated as a normal release binder matrix for the formulation of chloroquine phosphate tablet and was compared with sodium carboxymethylcellulose (NaCMC) as a standard. Matrix formulations of chloroquine phosphate were prepared with 1%w/w, 2% w/w, 3%w/w and 4%w/w of Chloroquine of both the defatted Detarium microcarpium seed gum and NaCMC respectively. The granules prepared were standardized by evaluating their micromeritic properties using indices such as bulk and tapped densities, flow rate, angle of repose, Carrs index, Hausners ratio and percentage of fines. Tablets compressed there from were evaluated using the necessary unofficial and official indices (B.P. 2009) for normal uncoated compressed tablets. Results showed that both defatted Detarium microcarpium seed gum and NaCMC had good binding properties and tablet hardness which improved with increase in binder concentration (4% > 3% > 2% > 1% w/w).
carboxymethylcellulose; chloroquine; Detarium microcarpium gum; excipient; plant gum; unclassified drug; article; bulk density; Caesalpinia; controlled study; Detarium microcarpium; drug dosage form comparison; drug solubility; flow rate; hydrophilicity; matrix tablet; standardization; tablet compression; tablet disintegration time; tablet formulation; tablet friability; tablet hardness