Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Nigeria
Adeleye, A.O., Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Nigeria; Odeniyi, M.A., Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Nigeria; Jaiyeoba, K.T., Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Nigeria
The paper present a study regarding the binding properties of Cissus gum, obtained from Cissus populnea (Vitaceae), in paracetamol tablet formulations in comparison with official gelatin. Compressional properties were analyzed using density measurements and compression equations of Heckel. The mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while drug release properties were assessed using disintegration and dissolution times. Formulations containing Cissus gum exhibited faster onset and higher amount of plastic deformation during compression when compared with those of gelatin. The crushing strength, disintegration and dissolution times of the tablets increased with binder concentration while friability values decreased. Cissus gum tablets presented faster disintegration and higher crushing strength-friability ratio (CSFR) values than those containing gelatin. The dissolution profiles of formulations containing the two binders showed similarity factors above 50. Cissus gum would be a better alternative to gelatin in producing uncoated tablets for which the fast release is essential.