Onyishi V.I., Chime S.A., Odika F.C., Obitte N.C.
Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria
Onyishi, V.I., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria; Chime, S.A., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria; Odika, F.C., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria; Obitte, N.C., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria
The aim of the study was to formulate acetaminophen paediatric suspension using gum from Irvingia wombolu as suspending agent. Gum extracts from Irvingia wombolu seed cotyledons was used at concentrations of 1.6 and 3% in acetaminophen paediatric suspension. The suspending properties of Irvingia wombolu gum were compared to the properties of its mixtures with acacia and sodium carboxymethyl cellulose (SCMC). The phytochemical analysis of Irvingia wombolu gum and the effects of aging on the viscosity of the suspension formulations were studied. From the results, phytochemical analysis showed that the gum contains alkaloids, flavonoids, saponin, tannins and glycosides. The rheological properties of the suspensions showed that the viscosity of the suspensions were stable and did not show significant reduction over time (p < 0.05). The results of sedimentation volume of suspension showed that batch K formulated with Irvingia wombolu gum alone exhibited high stability and hence showed low sedimentation rate over time. Suspensions formulated with Irvingia wombolu gum exhibited properties comparable to those formulations containing mixtures of the three suspending agents (p < 0.05). Therefore, Irvingia wombolu gum can be used alone or with mixtures of acacia and SCMC as suspending agents in acetaminophen suspension for paediatrics.
alkaloid; carboxymethylcellulose; flavonoid; glycoside; paracetamol; polysaccharide; resin; saponin; steroid; tannin derivative; terpenoid; aging; article; controlled study; cotyledon; drug formulation; flow kinetics; Irvingia wombolu; mango; particle size; pH; phytochemistry; reaction time; sedimentation rate; suspension; temperature sensitivity; viscosity