Narayanaswamy V.K., Gleiser R.M., Kasumbwe K., Aldhubiab B.E., Attimarad M.V., Odhav B.
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South Africa; CREAN-IMBIV (CONICET-UNC), Facultad de Ciencias Agropecuarias, Universidad Nacional de Córdoba, Avenida Valparaíso s/n, Córdoba, Argentina
Narayanaswamy, V.K., Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia, Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South Africa; Gleiser, R.M., CREAN-IMBIV (CONICET-UNC), Facultad de Ciencias Agropecuarias, Universidad Nacional de Córdoba, Avenida Valparaíso s/n, Córdoba, Argentina; Kasumbwe, K., Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South Africa; Aldhubiab, B.E., Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Attimarad, M.V., Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Odhav, B., Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South Africa
Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate. © 2014 Venugopala K. Narayanaswamy et al.
3 (2 aminothiazol 4 yl) 6 bromo 2h chromen 2 one; 3 (2 bromoacetyl) 2h chromen 2 one; 3 (2 bromoacetyl) 6 chloro 2h chromen 2 one; 3 acetyl 6 bromo 2h chromen 2 one; 3 acetyl 6 chloro 2h chromen 2 one; 6 bromo 3 (2 bromoacetyl) 2h chromen 2 one; 6 bromo 3 (2,2 dibromoacetyl) 2h chromen 2 one; 6,7 methoxy coumarin; coumarin derivative; halide; insect repellent; larvicidal agent; scopoletin; unclassified drug; virus vector; coumarin derivative; insect repellent; insecticide; animal experiment; animal model; Anopheles arabiensis; Article; clinical evaluation; controlled study; drug exposure; drug screening; female; insecticidal activity; insecticide resistance; life cycle stage; malaria; mortality; mosquito; nonhuman; pharmacological parameters; vector control; animal; Anopheles; chemistry; human; livestock; mosquito; synthesis; Animalia; Anopheles arabiensis; Animals; Anopheles; Coumarins; Humans; Insect Repellents; Insecticides; Livestock; Mosquito Control