Department of Pharmaceutic and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
Okunlola, A., Department of Pharmaceutic and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria; Odeku, O.A., Department of Pharmaceutic and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
Starches form four Dioscorea species namely Dioscorea dumetorum (bitter yam), D. oppositifolia (Chinese yam), D. alata (water yam) and D. rotundata (white yam) have been evaluated as disintegrants in chloroquine phosphate tablet formulations in comparison with official corn starch. The mechanical and drug release properties of the tablets were assessed. Tile results showed that the ranking of the effectiveness of the starches as intragranular disintegrant was water > white > corn > Chinese> bitter. The disintegrant concentration had significant (p < 0.001) effects on the disintegrant efficiency. The four experimental starches compared favorably and in some cases showed better efficiency as intragranular disintegrant than corn starch and could be further developed for use in commercial tablet formulation.
chloroquine; starch; water; article; bitter taste; Chinese; comparative study; controlled study; corn; Discorea alata; Discorea dumetorum; Discorea oppositifolia; Discorea rotundata; drug formulation; drug release; drug solubility; nonhuman; species difference; tablet disintegration; tablet formulation; yam