Shmendi A., Pirie F., Naidoo D.P., Tlou B., Pilloy W., Motala A.A.
Department of Medicine, University of KwaZulu-Natal, Durban, South Africa; Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa; Department of Cardiology, University of KwaZulu-Natal, Durban, South Africa; Department of Biostatistics, University of KwaZulu-Natal, Durban, South Africa; Department of Nuclear Medicine, University of KwaZulu-Natal, Durban, South Africa
Shmendi, A., Department of Medicine, University of KwaZulu-Natal, Durban, South Africa; Pirie, F., Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa; Naidoo, D.P., Department of Cardiology, University of KwaZulu-Natal, Durban, South Africa; Tlou, B., Department of Biostatistics, University of KwaZulu-Natal, Durban, South Africa; Pilloy, W., Department of Nuclear Medicine, University of KwaZulu-Natal, Durban, South Africa; Motala, A.A., Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa
Background: The relationship between myocardial perfusion imaging (MPI) abnormalities, diabetes mellitus, and glucose control in South African populations is unknown. It was hypothesized that in subjects undergoing MPI for suspected coronary artery disease (CAD), those with diabetes would have more extensive perfusion defects and that diabetes control would influence MPI abnormalities. The aim of this study was to examine the relationship between the severity of CAD diagnosed with MPI in subjects with and without diabetes and to determine the relationship between diabetes control and extent of CAD.Methods: This study was a retrospective chart review of 340 subjects in whom MPI scans were performed over a 12-month period.Results: Subjects with diabetes had a higher prevalence of abnormal MPI, with more extensive ischemia, compared with subjects without diabetes (85.6% versus 68%; odds ratio 2.81, P,0.01). Glycated hemoglobin $7.0% was associated with a higher risk of abnormal MPI, with more extensive ischemia, compared with subjects having diabetes and glycated hemoglobin, 7.0% (odds ratio 2.46, P=0.03) and those without diabetes (odds ratio 4.55, P=0.0001).Conclusion: Subjects with diabetes have more extensive myocardial ischemia when compared with subjects without diabetes. Furthermore, poorer diabetes control is associated with more abnormalities on MPI scanning. © 2014 Shmendi et al.
glucose; glycosylated hemoglobin; hemoglobin A1c; low density lipoprotein cholesterol; adult; Article; body mass; cardiovascular risk; cholesterol blood level; controlled study; coronary artery disease; diabetes mellitus; disease duration; disease severity; female; glucose blood level; glycemic control; heart muscle ischemia; human; image analysis; image quality; imaging system; major clinical study; male; myocardial perfusion imaging; population research; prevalence; retrospective study; risk assessment; risk factor; smoking; South African; systolic blood pressure