Joint modelling of repeated measurements and event time: Application to performance traits and survival of lambs bred in sub-humid tropics
Genetics Selection Evolution
Department of Mathematics, University of Nairobi, Nairobi, Kenya; Center for Statistics, Limburgs Universitair Centrum, Diepenbeek, Belgium; Intl. Livestock Research Institute, Nairobi, Kenya
We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis. The available data include information on time to death and repeated measurements of body weight, packed cell volume (PCV) and faecal egg count (FEC) of the animals. In the paper, we consider joint modelling of the survival time and the repeated measurements. Such an approach allows to account for the possible association between the survival and repeated measurement processes. The advantages and limitations of the joint modelling are discussed and illustrated using the Diani Estate study data. © INRA, EDP Sciences, 2005.
parasite resistance; selective breeding; sheep; survival; animal; animal disease; animal parasitosis; article; biological model; body weight; comparative study; cross breeding; genetic predisposition; genetics; genotype; hematocrit; Kenya; mortality; parasite identification; parasitology; sheep; sheep disease; tropic climate; Animals; Body Weight; Crosses, Genetic; Genetic Predisposition to Disease; Genotype; Helminthiasis, Animal; Hematocrit; Kenya; Models, Biological; Parasite Egg Count; Sheep; Sheep Diseases; Tropical Climate; Africa; East Africa; Eastern Hemisphere; Kenya; Sub-Saharan Africa; World; Ovis aries