Evaluation of lipoxygenase inhibitory activity of anacardic acids
Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3114, United States; School of Material Sciences, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923-1292, Japan; Department of Chemistry, University of the Western Cape, P/Bag X17, Bellville, 7530, South Africa
6-Alkylsalicylic acids inhibit the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 184.108.40.206, type 1) competitively and without pro-oxidant effects. This activity is largely dependent on the nature of their alkyl side chains. Inhibitory activities of anacardic acids, viz. 6-pentadec(en)ylsalicylic acids, isolated from the cashew Anacardium occidentale, were initially used for comparison because their aromatic head portions are the same. Consequently, the data should be interpreted to mean that changes in the hydrophobic side chain tail portions of the molecules evaluated correlate with the specific activity determined. © 2008 Verlag der Zeitschrift für Naturforschung.
anacardic acid; lipoxygenase inhibitor; scavenger; article; chemistry; drug screening; electrospray mass spectrometry; Anacardic Acids; Drug Evaluation, Preclinical; Free Radical Scavengers; Lipoxygenase Inhibitors; Spectrometry, Mass, Electrospray Ionization; Anacardium occidentale; Glycine max