Kuppuram G., Dhunmati K., Jaison D., Kousalya M., Mohammad Yaseen A., Swetha S.
Department of Educational planning, Management Wolaita Sodo University, Ethiopia; College of pharmacy, Madras Medical College, Chennai -600003, India; Department of Biotechnology, Bharathidasan University, Tiruchirappalli, India
Kuppuram, G., Department of Educational planning, Management Wolaita Sodo University, Ethiopia; Dhunmati, K., College of pharmacy, Madras Medical College, Chennai -600003, India; Jaison, D., College of pharmacy, Madras Medical College, Chennai -600003, India; Kousalya, M., College of pharmacy, Madras Medical College, Chennai -600003, India; Mohammad Yaseen, A., College of pharmacy, Madras Medical College, Chennai -600003, India; Swetha, S., Department of Biotechnology, Bharathidasan University, Tiruchirappalli, India
Background: Helminth infections are most common infections in man which affects a large proportion of world's population which interrupts their quality of life. The aim of this study is to prove the anthelmintic activity of the roots of Ziziphus oenoplia linn (Rhamnaceae). Methods: Four groups each containing three earthworms of approximately same size were released into 10ml of desired formulation. Each group was treated with one of the following; Albendazole 40mg/ml in Carboxy Methyl Cellulose (CMC) as standard and ethanolic extracts 5mg/ml, 10mg/ml and 50mg/ml of the root powder Ziziphus oenoplia in CMC. The time taken for the paralysis and death of earthworm by ethonolic extract was compared with that of standard Albendazole. Result: The result of this study shows that the anthelmintic activity of the drug increases with increase in the concentration of ethanolic extract of the root powder of Ziziphus oenoplia. In comparison with the standard drug Albendazole, the time taken for the paralysis and death of the earthworm by the ethanolic extract is found to be desirable. Conclusion: The present investigation proves that the alcoholic extract of Ziziphus oenoplia, exerts significant activity against roundworm infections. We hope that in future the shrub Ziziphus oenoplia will be able to replace the anthelmintic drugs which have an increased risk of drug interactions.
albendazole; alcohol; carboxymethylcellulose; jujube extract; unclassified drug; Ziziphus oenoplia extract; anthelmintic activity; article; concentration response; controlled study; death; drug effect; earthworm; in vitro study; jujube; nematodiasis; nonhuman; paralysis; plant root; Ziziphus oenoplia