Comparative in vivo evaluation of the trypanocidal activities of aqueous leaf, stem-bark and root extracts of Khaya senegalensis on Trypanosoma evansi
Journal of Medicinal Plants Research
Animal Health and Husbandry Department, College of Agriculture and Animal Science, Ahmadu Bello University, P. M. B. 2134, Mando Road, Kaduna, Nigeria; Animal Production Technology Department, College of Agriculture and Animal Science, Ahmadu Bello Univer
The effects of three different parts of Khaya senegalensis, commonly used in the traditional treatment of diseases in Northern Nigeria was examined in Trypanosoma evansi infected rats. At a dose of 120 mg/ml body weight for 3 consecutive days, the aqueous stem bark extract completely suppressed parasite establishment. The dose cured the experimentally infected rats in 9 days. The aqueous leaf extract showed a weak trypanocidal activity while the stem bark extract showed the most activity that is dose dependent. The results suggested that traditional use of K. senegalensis extracts has a pharmacological basis. © 2010 Academic Journals.
alkaloid; antiprotozoal agent; carbohydrate; cardiac glycoside; diminazene aceturate; flavanoid; Khaya senegalensis extract; plant extract; samorenil; saponin; sugar; tannin derivative; terpene; unclassified drug; animal experiment; animal model; antiprotozoal activity; article; bark; chemical composition; comparative study; controlled study; drug dose comparison; drug efficacy; drug screening; female; Khaya senegalensis; male; nonhuman; phytochemistry; plant; plant leaf; plant root; plant stem; rat; surra; treatment duration; treatment response; Trypanosoma evansi; Khaya senegalensis; Rattus; Trypanosoma evansi