Department of Chemistry, University of Uyo, Uyo, Nigeria
Mkpenie, V.N., Department of Chemistry, University of Uyo, Uyo, Nigeria; Mkpenie, I.V., Department of Chemistry, University of Uyo, Uyo, Nigeria; Essien, E.E., Department of Chemistry, University of Uyo, Uyo, Nigeria
Schiff bases with ortho-, meta- and para-methyl substituents were synthesized by thecondensation of appropriatearomatic amines (o-, m- and p-toluidine) with benzaldehyde. The structures of all the synthesized compounds were confirmed by analytical and spectral data. The sensitivity of thebacteria and fungi was evaluated bymeasuring the zones of inhibition exhibited by the microorganisms against the tested compounds using disk diffusion method. The results of the antimicrobial activity showed that the methyl group substituted at meta and para positions exhibited more antifungal and antibacterial activities compared to the ortho and unsubstituted derivatives. The results showed that antifungal and antibacterial activities are affected by the position of substituents in the aryl ring of theSchiff bases.
2 methylaniline; 3 methylaniline; 4 methylaniline; aniline derivative; antiinfective agent; benzaldehyde; fluconazole; n (2 methylphenyl) 1 phenylmethanimine; n (3 methylphenyl) 1 phenylmethanimine; n (4 methylphenyl) 1 phenylmethanimine; n,1 diphenylmethanimine derivative; Schiff base; streptomycin; unclassified drug; antibacterial activity; antibiotic sensitivity; antifungal activity; antifungal susceptibility; Article; Aspergillus fumigatus; Aspergillus niger; Candida albicans; controlled study; disk diffusion; drug screening; drug structure; drug synthesis; Escherichia coli; nonhuman; Salmonella enterica serovar Typhi; Shigella dysenteriae; Staphylococcus aureus; Trichophyton rubrum