Green I.R., Tocoli F.E., Lee S.H., Nihei K.-i., Kubo I.
Department of Chemistry, University of the Western Cape, P/Bag X17, Bellville, 7530, South Africa; Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, United States
Green, I.R., Department of Chemistry, University of the Western Cape, P/Bag X17, Bellville, 7530, South Africa; Tocoli, F.E., Department of Chemistry, University of the Western Cape, P/Bag X17, Bellville, 7530, South Africa; Lee, S.H., Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, United States; Nihei, K.-i., Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, United States; Kubo, I., Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, United States
On the basis of antibacterial anacardic acids, 6-pentadecenylsalicylic acids, isolated from the cashew apple, Anacardium occidentale L. (Anacardiaceae), a series of 6-alk(en)ylsalicylic acids were synthesized and tested for their antibacterial activity against Streptococcus mutans ATCC 25175. Among them, 6-(4′,8′-dimethylnonyl)salicylic acid was found to exhibit the most potent antibacterial activity against this cariogenic bacterium with the minimum inhibition concentration (MIC) of 0.78 μg/ml. © 2007 Elsevier Masson SAS. All rights reserved.
anacardic acid; salicylic acid derivative; antibacterial activity; article; cashew nut; dental caries; drug design; drug isolation; drug screening; drug synthesis; minimum inhibitory concentration; nonhuman; Streptococcus mutans; Anacardic Acids; Anti-Bacterial Agents; Dental Caries; Drug Design; Drug Evaluation, Preclinical