Evaluation of Baylis-Hillman Routes to 3-(Aminomethyl)coumarin Derivatives
Department of Chemistry, University of Lagos, Lagos, Nigeria; Department of Chemistry and Center for Chemico, Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa
The relative merits of two different Baylis-Hillman approaches toward the preparation of coumarin derivatives, containing peptide-like side chains, have been explored. In one approach, use of methyl acrylate as the activated alkene requires a protecting group strategy, an approach that is not necessary when using tert-butyl acrylate. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] © 2014 Copyright Taylor and Francis Group, LLC.
3 (aminomethyl)coumarin derivative; acrylic acid butyl ester; acrylic acid methyl ester; coumarin derivative; unclassified drug; article; Baylis Hillman reaction; drug structure; nucleophilicity
62273, National Research Foundation