Olasupo I., Rose N.R., Klein R., Adams L.A., Familoni O.B., Kaye P.T.
Department of Chemistry, University of Lagos, Lagos, Nigeria; Department of Chemistry and Center for Chemico, Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa
Olasupo, I., Department of Chemistry, University of Lagos, Lagos, Nigeria; Rose, N.R., Department of Chemistry and Center for Chemico, Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa; Klein, R., Department of Chemistry and Center for Chemico, Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa; Adams, L.A., Department of Chemistry, University of Lagos, Lagos, Nigeria; Familoni, O.B., Department of Chemistry, University of Lagos, Lagos, Nigeria; Kaye, P.T., Department of Chemistry and Center for Chemico, Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa
The relative merits of two different Baylis-Hillman approaches toward the preparation of coumarin derivatives, containing peptide-like side chains, have been explored. In one approach, use of methyl acrylate as the activated alkene requires a protecting group strategy, an approach that is not necessary when using tert-butyl acrylate. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] © 2014 Copyright Taylor and Francis Group, LLC.