Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa
Kinfe, H.H., Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa; Belay, Y.H., Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa
Anovel series of thiosemicarbazone-triazole hybrids were efficiently synthesized and evaluated for their activity against the 3D7 strain of the malaria parasite, Plasmodium falciparum. Although the hybrids were found not to be as potent as the standard chloroquine, they have shown activities interesting enough to warrant future structure activity relationship (SAR) studies.