Synthesis and pesticidal evaluation of novel quin-8- oxytetramethyldiphenyldioxaphosphonine analogue
South African Journal of Chemistry
Department of Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria; Department of Chemistry, Bayero University Kano, P.M.B. 3011, Kano, Nigeria
Although a great deal of success has been achieved in the synthesis of dibenzodioxaphosphepin derivatives during the last few decades with the introduction of hundreds of its six-, and seven-membered ring systems, the search for more practical agronomic pesticides that is readily available and of good activity, remains attractive and important to an agronomic chemist. During the course of the development of synthetic routes to a promising pesticide, a facile preparation for a nine-membered heterocyclic dibenzodioxaphosphonine compound was discovered. Previously reported compounds consist of six- and seven-membered ring systems. The pure product was fully characterized by spectroscopic [IR, NMR (1H, 13C, 31P) and Mass] analyses. The pure compound possesses a LC50 value of 19.3 μg cm-3 in a brine shrimp lethality assay (BST). The preliminary field study on the cowpea weevil bioassay shows 51% success. Details of the synthetic route as well as bioassay results are reported herein.