Evaluation of buparvaquone (BUTA-Kel™ KELA, Belgium) as a treatment of East Coast fever in cattle, in the peri-urban of Dar Es Salaam city, Tanzania
Animal Disease Research Institute, P.O. Box 9254, Dar Es Salaam, Tanzania
Evaluation trials of the efficacy of buparvaquone (BUTA-kel™ KELA Laboratoria, N.V. Belgium), as a treatment of field cases of Theileria parva infection (East Coast fever - ECF) were carried out on 63 cattle in the peri-urban of Dar Es Salaam city, Tanzania, during the period November 2004 to August 2005. Thirty-two cattle (56%) received single-dose treatment (2.5 mg buparvaquone per kg body weight), while two and three-dose treatment with interval(s) of 48 h was given to 33% and 11% of total treated cattle, respectively; 38 cattle (60.3%) were treated at an early stage of the disease, while 25 cattle (39.7%) were treated at an advanced stage of the disease. The rectal body temperature of 90.5% of buparvaquone-treated cattle dropped to normal values (37.5-39.5 °C) by day 7 of treatment, and by day 15 of treatment 96.8% of treated cattle showed normal values. Pulmonary signs were observed in 8/68 (11.8%) of total ECF diagnosed cattle and were successfully treated, albeit with parvaquone plus frusemide (Fruvexon); were not included in final evaluation of the efficacy of BUTA-kel. The present evaluation trials record a recovery rate of 95.2%. Buparvaquone (BUTA-kel™ KELA Laboratoria, N.V. Belgium), therefore, records another efficacious and valuable alternative treatment against East Coast fever in Tanzania. © 2006 Elsevier B.V. All rights reserved.
buparvaquone; buta kel; furosemide; parvaquone; animal parasitosis; article; cattle disease; controlled study; convalescence; drug efficacy; female; fever; lung disease; lymph node; male; nonhuman; rectum temperature; Tanzania; Theileria parva; urban area; Animals; Antiprotozoal Agents; Cattle; Cattle Diseases; Female; Male; Naphthoquinones; Tanzania; Theileria parva; Theileriasis; Treatment Outcome; Bos taurus; Theileria parva