Evaluation of the in vitro anticancer activity of cyclometalated half-sandwich rhodium and iridium complexes coordinated to naphthaldimine-based poly(propyleneimine) dendritic scaffolds
Journal of Organometallic Chemistry
Department of Chemistry, University of Cape Town, Private Bag, Rondebosch, South Africa; Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Institute of Chemistry, University of Neuchatel, 51 Ave de Bellevaux, Neuchatel, Switzerland
The development of cyclometalated rhodium and iridium complexes from first- and second-generation naphthaldimine-based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)n (where n = 4 or 8, DAB = diaminobutane) has been accomplished. Four metallodendrimers were synthesised, viz. (Cp∗MCl)4Gn (1-4), by first reacting DAB-(NH2)n with napththaldehyde and subsequently metallating the Schiff-base dendrimers with the dimers [Cp∗MCl2]2 (where M = Rh or Ir). Related mononuclear complexes [Cp∗MCl(L)] (L = naphthaldimine) (5-6) were obtained in a similar manner. The molecular structures of 5 and 6 have been determined by single-crystal X-ray diffraction analysis and the in vitro anticancer activities of 1-6 were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines. © 2014 Elsevier B.V. All rights reserved.
Rhodium; Anticancer activities; Anticancer drug; Bio-organometallic chemistry; Cyclometalated; Half-sandwich; Metallodendrimers; Poly(propylene imine); Rhodium and iridium complexes; Iridium
66054, National Research Foundation