Chiririwa H., Moss J.R., Hendricks D., Smith G.S., Meijboom R.
Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa; Division of Medical Biochemistry, University of Cape Town, Private Bag X3, Observatory 7935, South Africa; Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, Auckland Park 2006, Johannesburg, South Africa
Chiririwa, H., Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa, Division of Medical Biochemistry, University of Cape Town, Private Bag X3, Observatory 7935, South Africa, Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, Auckland Park 2006, Johannesburg, South Africa; Moss, J.R., Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa; Hendricks, D., Division of Medical Biochemistry, University of Cape Town, Private Bag X3, Observatory 7935, South Africa; Smith, G.S., Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa; Meijboom, R., Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, Auckland Park 2006, Johannesburg, South Africa
The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)2], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 μM. © 2012 Elsevier Ltd. All rights reserved.