Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity
Transition Metal Chemistry
Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa; Division of Medical Biochemistry, University of Cape Town, Private Bag X3, Observatory 7935, South Africa; Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa
Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1-L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation-mass spectrometry (ESI-MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02-45.27 μM, and IC50 range of 10.03-68.54 μM for the KYSE450 cell lines. © 2012 Springer Science+Business Media Dordrecht.
Anticancer activities; Cell lines; In-vitro evaluation; Palladium complexes; Room temperature; Single crystal X-ray diffraction analysis; Square planar geometry; X-ray diffraction studies; Cell culture; Chlorine compounds; Mass spectrometry; Synthesis (chemical); X ray diffraction analysis; Palladium compounds