Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation
Journal of Organometallic Chemistry
Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa; Department of Medicine, University of Cape Town, K45, OMB, Groote Schuur Hospital, Observatory 7925, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa
Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes (3-5) were prepared through the cleavage of a chlorido-bridged palladium ferrocenylthiosemicarbazone intermediate (2) using various P-donor ligands. These compounds were screened for antiplasmodial activity against chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) Plasmodium falciparum strains, exhibiting biological activity in the low micromolar range. The compounds generally display well-resolved electrochemically reversible one-electron transfer processes for the ferrocenyl group. The half-wave potential for the Fe(II)/Fe(III) couple is electronically influenced by the type of P-donor group through the palladium(II) centre. © 2013 Elsevier B.V. All rights reserved.
Antiplasmodial activity; Bio-organometallic chemistry; Half-wave potential; Heterobimetallics; One-electron transfer; Palladium complexes; Plasmodium falciparum; Thiosemicarbazones; Bioactivity; Cyclic voltammetry; Iron compounds; Metallic compounds; Synthesis (chemical); Palladium compounds; Plasmodium falciparum