Hamidi H., Heravi M.M., Tajbakhsh M., Shiri M., Oskooie H.A., Shintre S.A., Koorbanally N.A.
Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran, Iran; Department of Chemistry, University of Mazandaran, Babolsar, Iran; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa
Hamidi, H., Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran, Iran; Heravi, M.M., Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran, Iran; Tajbakhsh, M., Department of Chemistry, University of Mazandaran, Babolsar, Iran; Shiri, M., Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran, Iran; Oskooie, H.A., Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran, Iran; Shintre, S.A., School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa; Koorbanally, N.A., School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa
Cyclocondensation of 2-chloroquinoline-3-carbaldehydes and 2-thiophenol/2-aminophenols led to the formation of benzo[2,3][1,4]thio- or oxazepino[7,6-b]quinolines. Ugi reaction of the latter compound with various carboxylic acids and isocyanides gave novel oxazepino[7,6-b]quinoline derivatives. All compounds were evaluated for their anti-bacterial and anti-fungal activities. Among them, compounds 4a, 4b and 4d showed moderate to good activity. © 2015 Iranian Chemical Society.