Department of Chemistry, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria; Department of Chemistry, Ekiti State University, Ado, Ekiti State, Nigeria
Ejelonu, B.C., Department of Chemistry, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria; Olagboye, S.A., Department of Chemistry, Ekiti State University, Ado, Ekiti State, Nigeria
Nove l cobalt(II) diphenylamine complexes have been synthesized in water-methanol medium and characterized on the basis of their elemental analysis, melting points, solubility tests, conductivity tests , UV-Visible and IR spectral studies. The antimicrobial activities of the cobalt (II) complexes were screened against Enterohaemorragic coli, Staphylococcus aureus, Clostridium tetani,Neisseria gonorrheae and Streptococcus pyogeus bacteria and Mucor, Rhizomucor, Aspergillus fumigates, Rhizopus, Sporothrix schenckii, Aspergillus flavus, Aspergillus terreus, Absidia, Aspergillus niger and Candida spp pathogenic fungi. The melting points or decomposition temperatures of the metal complexes fell between 89-101°C. The colors of the metal complexes range from blue to purple. The spectral results suggest the binding of diphenylamine(ligand) through the nitrogen atom to the cobalt(II) ions. The absorption bands observed in the Uv-Visible region are presumed to be due to charge transfer or intra-ligand transitions from the ligands or d-d transition from the metal ions.The metal complexes displayed proactive activities against the tested bacteria and fungi pathogens.
amoxicillin; antiinfective agent; cobalt complex; cobalt diphenylamine complex; diphenylamine derivative; ketoconazole; methanol; unclassified drug; water; Absidia; antibacterial activity; antifungal activity; Article; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Aspergillus terreus; Candida; Clostridium tetani; conductance; controlled study; drug solubility; drug synthesis; enterohemorrhagic Escherichia coli; infrared spectroscopy; ligand binding; melting point; Mucor; Neisseria gonorrhoeae; nonhuman; Rhizomucor; Rhizopus; Sporothrix schenckii; Staphylococcus aureus; Streptococcus pyogenes; ultraviolet spectroscopy; Absidia; Aspergillus; Aspergillus flavus; Aspergillus niger; Aspergillus terreus; Candida; Clostridium tetani; Fungi; Mucor; Neisseria gonorrhoeae; Rhizomucor; Rhizopus; Sporothrix schenckii; Staphylococcus aureus; Streptococcus