Patel V., Bhatt N., Bhatt P., Joshi H.D.
Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India; JJT University, Jhunjhunu, Rajasthan, India; School of Chemistry, University of KwaZulu-Natal, Westville Campus, Durban, South Africa
Patel, V., Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India; Bhatt, N., JJT University, Jhunjhunu, Rajasthan, India; Bhatt, P., School of Chemistry, University of KwaZulu-Natal, Westville Campus, Durban, South Africa; Joshi, H.D., Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India
Novel compounds of biological interest were synthesized by in situ reduction of Schiff's base of 5,6-dimethoxy indanone and 1-(piperidin-4-yl)-1H- benzo[d] imidazol-2(3H)-one in the presence of Ti(OiPr)4 and NaBH3CN. Further alkylation using different alkyl/aryl halides in the presence of NaH in DMF gave a series of novel compounds. A formation of newly synthesized compounds was confirmed on the basis of their spectral and elemental analysis. Further these compounds were screened for their antimicrobial activity and found to have promising antibacterial and antifungal activity. © Springer Science+Business Media 2013.
1 (piperidin 4 yl) 1h benzo[d]imidazol 2(3h) one derivative; 3 benzyl 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 1h benzo[d]imidazol 2(3h) one; 3 butyl 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 3 (3 (dimethylamino)propyl 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 3 (4 nitrobenzyl) 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 3 (methoxymethyl) 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 3 isobutyl 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 3 propyl 1h benzo[d]imidazol 2(3h) one; 5 chloro 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1yl)piperidin 4 yl) 3 ethyl 1h benzo[d]imidazol 2(3h) one; 5 chloro 3 (2 chloroethyl) 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 1h benzo{d]imidazol 2(3h) one; 5 chloro 3 (4 chlorobenzyl) 1 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 1h benzo[d]imidazol 2(3h) one; 6 chloro 3 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) n,n diethyl 2 oxo 2,3 dihydro 1h benzo[d]imidazole 1 carboxamide; antiinfective agent; ethyl 2 (6 chloro 3 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl) 2 oxo 2,3 dihydro 1h benzo[d]imidazol 1 yl)acetate; ethyl 6 chloro 3 (1 (5,6 dimethoxy 2,3 dihydro 1h inden 1 yl)piperidin 4 yl)2 oxo 2,3 dihydro 1h benzo[d]imidazole 1 carboxylate; imidazole derivative; Schiff base; unclassified drug; alkylation; antibacterial activity; antifungal activity; antimicrobial activity; article; drug screening; drug synthesis