Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression
Alcohol Tobacco and Other Drug Research Unit, Medical Research Council, Cape Town, South Africa; Centre for Social Science Research, Department of Sociology, University of Cape Town, Cape Town, South Africa; Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, United States
The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA. © 2015 Kader et al.
antiretrovirus agent; acquired immune deficiency syndrome; adult; alcohol abuse; Article; CD4 lymphocyte count; controlled study; cross-sectional study; disease course; drug abuse; drug treatment failure; female; human; human cell; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; major clinical study; male; patient attitude; patient compliance; prediction; South Africa; substance abuse; treatment response
5U2GPS001137, CDC, Centers for Disease Control and Prevention