Evaluation of hypolipidemic and potential antioxidant effects of Pigeon pea (Cajanus cajan (l) mill sp.) leaves in alloxan-induced hyperglycemic rats
Journal of Medicinal Plants Research
Department of Biochemistry, College of Natural Sciences, University of Agriculture, P. M. B. 2240 Abeokuta, Ogun-State, Nigeria
Antioxidant and hypolipidemic activity of the methanolic leaf extract from Cajanus cajan was carried out in alloxan induced hyperglycemic rats. A significant (p<0.05) reduction in the levels of blood glucose, serum triglyceride, cholesterol, high density lipoprotein and low density lipoprotein cholesterol was observed in the hyperglycemic-extract treated rats. The administration of the extract (200 mg/kg) also caused a reduction in urea, creatinine and malondialdehyde levels in hyperglycemic rats. The extract was found to be able bring about 34.4 and 32.16% decrease in the activities of ALT and AST respectively in the hyperglycemic-treated rats compared to untreated group. Antioxidant activity of the extract was also confirmed through in vitro studies. © 2011 Academic Journals.
alanine aminotransferase; alloxan; antioxidant; aspartate aminotransferase; Cajanus cajan extract; creatinine; glibenclamide; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; malonaldehyde; plant extract; triacylglycerol; unclassified drug; urea; animal experiment; animal model; antioxidant activity; article; cholesterol blood level; controlled study; creatinine blood level; drug efficacy; drug safety; enzyme activity; glucose blood level; hyperglycemia; hypolipemia; in vitro study; male; nonhuman; pigeonpea; plant leaf; protein blood level; rat; solvent extraction; treatment response; triacylglycerol blood level; urea blood level; Cajanus cajan; Rattus