Omonkhua A.A., Adesunloro C.A., Osaloni O.O., Olubodun S.O.
Department of Biochemistry, Adekunle Ajasin University, P.M.B. 001, Akungba-Akoko, Ondo State, Nigeria; Department of Food Science and Technology, Edo State Institute of Technology and Management, Usen, Edo State, Nigeria
Omonkhua, A.A., Department of Biochemistry, Adekunle Ajasin University, P.M.B. 001, Akungba-Akoko, Ondo State, Nigeria; Adesunloro, C.A., Department of Biochemistry, Adekunle Ajasin University, P.M.B. 001, Akungba-Akoko, Ondo State, Nigeria; Osaloni, O.O., Department of Biochemistry, Adekunle Ajasin University, P.M.B. 001, Akungba-Akoko, Ondo State, Nigeria; Olubodun, S.O., Department of Food Science and Technology, Edo State Institute of Technology and Management, Usen, Edo State, Nigeria
The effects of aqueous extracts of Hibiscus sabdariffa L. calyces in cadmium-induced oxidative damage in serum and tissues of rats were evaluated in this study. Twenty eight male Wister rats (170-200 g) in four groups, {control (I), Hibiscus sabdariffa (II), Cadmium (III) and H. sabdariffa+Cd (IV)}, were used. Groups II and IV were given a daily dose of 0.2 g kg-1 body weight of H. sabdariffa extracts for four weeks, while groups III and IV (the Cd groups) were injected sub-cutaneously with 0.002 g Cd (as CdSO4 8H2O) kg-1 body weight once a week for four weeks. Liver protein levels significantly (p<0.05) decreased for all test groups relative to control, while the kidney and testis protein levels significantly (p<0.05) increased. There was a general increase in serum and tissue malondialdehyde (MDA) levels of tests groups relative to control while a general decrease was observed in serum and tissue catalase activities. Serum SOD of tests groups significantly (p<0.05) decreased while tissue SOD significantly (p<0.05) increased compared to control. The results showed, for some parameters evaluated, that H. sabdariffa appeared to play a protective role against Cd-induced oxidative damage. Paradoxically, however, H. sabdariffa alone also appeared to exert some measure of oxidative damage. © 2009 Asian Network for Scientific Information.
cadmium; catalase; Hibiscus sabdariffa extract; malonaldehyde; superoxide dismutase; animal experiment; animal model; animal tissue; antioxidant activity; article; cadmium poisoning; controlled study; enzyme activity; enzyme blood level; kidney; lipid peroxidation; liver; male; nonhuman; oxidative stress; protection; rat; testis; Hibiscus sabdariffa; Rattus