Department of Applied Science, CST, Kaduna Polytechnic, Kaduna, Nigeria; Department of Pharmacognosy, Drug Development Ahmadu Bello University, Nigeria
Nuhu, A.M., Department of Applied Science, CST, Kaduna Polytechnic, Kaduna, Nigeria; Ilyas, N., Department of Pharmacognosy, Drug Development Ahmadu Bello University, Nigeria; Ibrahim, H., Department of Pharmacognosy, Drug Development Ahmadu Bello University, Nigeria
The n-butanol phase of the methanolic leaves extract of Microtrichia perotitii DC was studied for its analgesic and anti-inflammatory activities. Both percent inhibition obtained from analgesic (59.30% for 100 mg/kg, 33.90% for 50 mg/kg and 69.20% for 25 mg/kg i.p) and anti-inflammatory (values for 25, 50 and 100 mg/kg were found significantly different at P < 05, P < 0.01 and P < 0.001) (mean paw diameter in hours) studies has shown that the leaves have very strong activity to prevent pains (writhing) in the central system and motor performance of the mice as well as the growth of oedema in the hind paw of the rats respectively. The analgesic effect is dosage independent while the anti-inflammatory effect is dosage dependent and all these activities could be associated with the type of phytochemicals likely to be present in the leaves of plant. © 2010 Academic Journals.
acetic acid; alkaloid; analgesic agent; antiinflammatory agent; butanol; ether; flavonoid; hydrochloric acid; ketoprofen; methanol; Microtrichia perotitii extract; piroxicam; plant extract; saponin; sodium chloride; unclassified drug; water; analgesic activity; animal experiment; animal model; antiinflammatory activity; article; Asteraceae; central nervous system; controlled study; dose response; drug dose comparison; drug efficacy; drug megadose; female; inflammation; low drug dose; male; Microtrichia perotitii; motor performance; mouse; nonhuman; pain; paw edema; phytochemistry; plant leaf; rat; writhing test; Asteraceae; Mus; Rattus