Spermatotoxic impact of bonny light crude oil (BLCO) ingestion on adult male Swiss albino mice
International Journal of Physical Sciences
Department of Anatomy, Olabisi Onabanjo University, College of Medicine, Ogun, Nigeria; Department of Anatomical Sciences, University of Abuja, College of Health Sciences Gwagwalada, P. O. Box 882, Gwagwalada, Abuja, Nigeria; Nigerian Medical Research Ins
Increasing concern has been expressed about the possible declining trend in the sperm quality and sperm count of man as a result of exposure to environmental estrogenic agents in the past few years now. There is a general paucity of knowledge of BLCO ingestion on the reproductive effect. Hence, we aim to evaluate the impact of sub-lethal dose of BLCO ingestion on semen parameters of adult male mice. Initial acute toxicity study was carried out to determine the lethal dose of BLCO, which was calculated to be 37.4 mg/Kg body wt. A sub-lethal dose of 20 mg/Kg bwt /day of BLCO were then given to 8 male mice in the experimental group. While,the control group of 7 animals received equal volume of 0.9% normal saline via oral garvage for 2 weeks. Data were analysed using SPSS 12 statistical software with P >0.05 considered statistically significant. There was a significant (P >0.05) weight gain in the treated group with a significant (P >0.05) reduction in sperm motility in the treated compared with control. The sperm density of treated and control were 14.5 × 106ml and 20.5 × 106 /ml respectively. However, there were also no significant difference in the relative testicular weight and sperm density of treated from that of the control respectively. Thus, it was concluded that BLCO ingestion is spermatotoxic in the adult male Swiss mice © 2009 Academic Journals..