Ukwenya V., Ashaolu O., Adeyemi D., Obuotor E., Tijani A., Biliaminu A., Caxton-Martins E.
Department of Anatomy, Faculty of Basic Medical Sciences, Bowen University, Iwo, Nigeria; Department of Anatomy, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria; Department of Biochemistry, Bowen University, Iwo, Nigeria; D
Ukwenya, V., Department of Anatomy, Faculty of Basic Medical Sciences, Bowen University, Iwo, Nigeria; Ashaolu, O., Department of Anatomy, Faculty of Basic Medical Sciences, Bowen University, Iwo, Nigeria; Adeyemi, D., Department of Anatomy, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria; Obuotor, E., Department of Anatomy, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria; Tijani, A., Department of Biochemistry, Bowen University, Iwo, Nigeria; Biliaminu, A., Department of Clinical Pathology, Faculty of Basic Medical Sciences University of Ilorin, Ilorin, Nigeria; Caxton-Martins, E., Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria
Anti-diabetic and antioxidant properties. The objective of this work was to determine the effects of Anacardium occidentale leaf extract (AOLE) on the activities of glucose-6-phosphate dehydrogenase (G-6-PDH), thiobarbituric acid reactive substances (TBARS) and anti-oxidant enzymes (Glutathione peroxidase, GPx and superoxide dismutase, SOD) in the testicular homogenate of streptozotocin-induced diabetic rats. Forty (40) wistar rats (Rattus norvegicus) were randomly divided into four experimental groups. Diabetes was induced by a single intraperitoneal injection of Streptozotocin (70 mg/kg b.w.). Five days after the confirmation of hyperglycemia, Groups A and B were treated with 300 mg/kg b.w of the extract and 1 I.U/kg b.w. insulin respectively. Groups C and D served as hyperglycemic and normal controls respectively. Animals were sacrificed 16 days after treatment. Our study showed that AOLE ameliorated the level of TBARS and improved the activities of G-6-PDH, SOD and GPx in the testes of extract-treated rats.
Anacardium occidentale leaft extract; antioxidant; enzyme; glucose; glucose 6 phosphate dehydrogenase; isophane insulin; peroxidase; plant extract; superoxide dismutase; thiobarbituric acid reactive substance; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antioxidant activity; article; controlled study; drug effect; enzyme activity; glucose blood level; hyperglycemia; male; nonhuman; oxidative stress; rat; streptozocin diabetes; testis