Performance of the CardioChek™ PA and Cholestech LDX® point-of-care analysers compared to clinical diagnostic laboratory methods for the measurement of lipids
Cardiovascular Journal of South Africa
Carbohydrate and Lipid Metabolism Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa; National Health Laboratory Services, Department of Chemical Pathology, University of the Witwatersrand, Johannesburg, South Africa
Point-of-care (POC) blood testing is intended to provide results more rapidly than can be obtained from a central laboratory. Precision and accuracy of the CardioChek PA and Cholestech LDX analysers were compared to clinical diagnostic laboratory methods. In 100 patients, total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) levels were measured by both analysers and compared to those analysed by the National Health Laboratory Service (NHLS) laboratory. Data were evaluated for conformance with National Cholesterol Education Program (NCEP) guidelines. Results were grouped into low, middle and high ranges and were similar to those obtained by the NHLS, except in the high range where TC and LDL-C levels were under-read by both analysers. All analytes measured by both analysers correlated significantly with NHLS (p < 0.0001). With the exception of LDL-C, both analysers showed reasonable compliance with NCEP goals for coefficients of variation and bias measurements. Both analysers met NCEP guidelines for all analytes at two clinical cut-off points. We concluded that, compared to NHLS methods, performance of the CardioChek PA and Cholestech LDX analysers is acceptable and that they offer healthcare professionals a rapid, POC method for the measurement of lipids.
high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; biological marker; lipid; analytic method; article; blood testis barrier; cholesterol blood level; controlled study; diagnostic accuracy; hospital information system; human; laboratory test; lipid analysis; major clinical study; triacylglycerol blood level; blood; blood examination; comparative study; diagnosis, measurement and analysis; evaluation; hyperlipoproteinemia type 2; methodology; sensitivity and specificity; Biological Markers; Hematologic Tests; Humans; Hyperlipoproteinemia Type II; Laboratory Techniques and Procedures; Lipids; Point-of-Care Systems; Sensitivity and Specificity