Performance of a rapid self-test for detection of Trichomonas vaginalis in South Africa and Brazil
Journal of Clinical Microbiology
CUNY School of Public Health at Hunter College, New York, NY, United States; University of California, San Francisco, San Francisco, CA, United States; University of São Paulo School of Medicine, São Paulo, Brazil; Centre for Evidence-Based Health Care, Stellenbosch University, Stellenbosch, South Africa; Acad. Med. Ctr. of the Univ. of Amsterdam and Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands; Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
Women participating in studies in Brazil (n∇695) and South Africa (n∇230) performed rapid point-of-care tests for Trichomonas vaginalis on self-collected vaginal swabs. Using PCR as the gold standard, rapid self-testing achieved high specificity (99.1%; 95% confidence interval [CI], 98.2 to 99.6%) and moderate sensitivity (76.7%; 95% CI, 61.4 to 88.2%). These tests may be considered an alternative to syndromic management in resource-poor settings.
adolescent; adult; article; Brazil; controlled study; diagnostic test accuracy study; dysuria; female; human; lower abdominal pain; major clinical study; nonhuman; parasite identification; point of care testing; polymerase chain reaction; predictive value; priority journal; rapid test; resource allocation; sensitivity and specificity; South Africa; test strip; Trichomonas vaginalis; vagina discharge; vagina smear; vaginal pruritus; Adolescent; Adult; Brazil; Female; Humans; Parasitology; Point-of-Care Systems; Self-Examination; Sensitivity and Specificity; South Africa; Trichomonas vaginalis; Trichomonas Vaginitis; Young Adult